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Perhexiline maleate

CAS No. 6724-53-4

Perhexiline maleate( WSM 3978G )

Catalog No. M15566 CAS No. 6724-53-4

Perhexiline maleate (WSM 3978G) is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Perhexiline maleate
  • Note
    Research use only, not for human use.
  • Brief Description
    Perhexiline maleate (WSM 3978G) is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2).
  • Description
    Perhexiline maleate (WSM 3978G) is a prophylactic antianginal agent that inhibits carnitine palmitoyltransferase (CPT1/CPT2); promotes HER3 ablation through receptor internalization and inhibits tumor growth; activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.Hypertension Phase 2 Clinical.
  • In Vitro
    Cell Viability Assay Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2, 4, 6 h Result:Induced time- and concentration-dependent cytotoxicity in hepatic cells.Western Blot Analysis Cell Line:HepG2 cells Concentration:5, 10, 15, 25 μM Incubation Time:2 h Result:Reduced Bcl-2 and Mcl-1 level, and increased Bad level.
  • In Vivo
    Animal Model:Orthotopic glioblastoma mouse modelDosage:80 mg/kg Administration:Oral gavage, for 3 days. Result:Reduces tumor size (MR imaging) and improves in overall survival.
  • Synonyms
    WSM 3978G
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypertension

Chemical Information

  • CAS Number
    6724-53-4
  • Formula Weight
    393.568
  • Molecular Formula
    C23H39NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 25 mg/mL (63.52 mM)
  • SMILES
    C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3.C(=CC(=O)O)C(=O)O
  • Chemical Name
    2-(2,2-dicyclohexylethyl)-piperidine maleate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Guo Y, et al. J Clin Invest. 2015 Oct 1;125(10):3819-30. 2. Hamdan M, et al. Pharmacol Res. 2001 Aug;44(2):99-104.
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